Parvovirus B19, a member of the Erythrovirus genus, is the only member of the Parvoviridae family known to be pathogenic in humans. Erythroviruses are so named because of their tropism and selective replication in erythroid progenitor cells. Haematological consequences of B19 infection arise due to a direct cytotoxic e€ect on erythroid progenitors in bonemarrow with interruption of erythrocyte production. This result in what is called transient aplastic attack. Other important issue about PB 19 is its association acute leukemia with hematological consequences before development of the disease, during and after chemotherapy.
Parvovirus b19 and hematological Disorders in children
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